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AntioxidantINS 321
E321
BHT (butylated hydroxytoluene)
What you need to know
BHT is a synthetic antioxidant closely related to BHA, used in chewing gum, cereals and packaging fats.
Unlike BHA, the cancer agency IARC reviewed BHT and found it not classifiable as a carcinogen (Group 3). Regulators permit it with one of the lower intake limits among antioxidants.
Many manufacturers have replaced it with vitamin E in recent years.
Where it stands, by region
The same additive can be approved in one country and banned in another. This is the divergence that matters most.
| 🇦🇺AU / NZ | Approved Permitted (FSANZ Food Standards Code). |
| 🇪🇺EU | Approved Permitted with strict maximum levels; ADI 0.25 mg/kg bw/day (2012). |
| 🇺🇸US | Approved Permitted (FDA). |
| 🇨🇦CA | Approved Permitted (Health Canada). |
Health evidence
How settled the science is for each area — not how dangerous. “Unknown” means not enough good studies yet.
Hyperactivity & behaviour
Unknown
Allergy & intolerance
Unknown
Gut microbiome
Unknown
Metabolic effects
Suspected
Carcinogenicity
IARC Group 3 — not classifiable
Suspected
Cardiovascular
Unknown
2,6-di-tert-butyl-4-methylphenol. ADI 0.25 mg/kg bw/day (EFSA 2012). IARC Group 3 (not classifiable).
Synthesis: SyntheticADI 0.25 mg/kg bw/day