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Flavour enhancerINS 621
E621

Monosodium glutamate

What you need to know

MSG is the sodium salt of glutamate, an amino acid found naturally in tomatoes, cheese and seaweed. It adds the savoury “umami” taste.

Despite its reputation, large reviews have not found reliable evidence that MSG causes the symptoms once blamed on it in typical food amounts. Regulators class it as safe.

It does add sodium, so it counts toward salt intake.

Where it stands, by region

The same additive can be approved in one country and banned in another. This is the divergence that matters most.

🇦🇺AU / NZApproved
Permitted; must be declared on label.
🇪🇺EUApproved
Permitted with maximum levels (EFSA set a group ADI in 2017).
🇺🇸USApproved
GRAS; must be declared on label.
🇨🇦CAApproved
Permitted; must be declared.

Health evidence

How settled the science is for each area — not how dangerous. “Unknown” means not enough good studies yet.

Hyperactivity & behaviour
Unknown
Allergy & intolerance
Suspected
Gut microbiome
Unknown
Metabolic effects
Unknown
Carcinogenicity
Unknown
Cardiovascular
Adds to sodium intake
Suspected

Sodium salt of glutamic acid. Produced by bacterial fermentation of starch/sugar. JECFA: ADI “not specified” (lowest concern category). EFSA set a group ADI of 30 mg/kg bw/day in 2017.

Synthesis: Fermentation-derivedADI Acceptable (no numerical limit)