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Flavour enhancerINS 627
E627
Disodium guanylate
What you need to know
Disodium guanylate boosts savoury “umami” taste and is almost always paired with MSG, letting it work at lower levels.
It occurs naturally in dried mushrooms and fish.
Regulators consider it low concern.
Where it stands, by region
The same additive can be approved in one country and banned in another. This is the divergence that matters most.
| 🇦🇺AU / NZ | Approved Permitted (FSANZ Food Standards Code). |
| 🇪🇺EU | Approved Permitted (EFSA). |
| 🇺🇸US | Approved Permitted (FDA). |
| 🇨🇦CA | Approved Permitted (Health Canada). |
Health evidence
How settled the science is for each area — not how dangerous. “Unknown” means not enough good studies yet.
Hyperactivity & behaviour
Unknown
Allergy & intolerance
Suspected
Gut microbiome
Unknown
Metabolic effects
Unknown
Carcinogenicity
Unknown
Cardiovascular
Unknown
Disodium salt of guanosine 5′-monophosphate. JECFA ADI 'not specified'.
Synthesis: Fermentation-derivedADI Not specified (acceptable)